In March 2013, the DFG (German Research Foundation) established the new Research Unit "cGMP Signalling in Cell Growth and Survival" (FOR 2060). The consortium works on eight scientific projects at four locations in Germany; five research groups at the University of Tübingen collaborate with groups in Hamburg, Würzburg, and Frankfurt. The team focuses on the complex functions of cGMP in the control of cell growth, differentiation and survival.
The connecting goal of all projects is to dissect how cGMP affects tissue remodelling, degeneration and regeneration within the cardiovascular, nervous and neurosensory system.
The following key questions will be addressed:
- Which cGMP-generating receptors and ligands regulate specific processes of cell growth, differentiation and survival within the cardiovascular, nervous and neurosensory system of an intact mammalian organism?
- What are the immediate cGMP targets and downstream mechanisms?
- Which role does intracellular cGMP compartmentation play in the above processes and which mechanisms account for spatiotemporal and functional cGMP compartments?
- Are cGMP formation, compartmentation and signalling pathways altered in specific "degenerative" cardiovascular, neuronal and neurosensory diseases? Are these disorders affected by treatment with cGMP-modulating drugs?