Prof. Dr. Andreas Friebe

Physiologisches Institut
Universität Würzburg
Röntgenring 9, 97070 Würzburg


Tel.:       0931-3188730
Fax:       0931-3182741
E-Mail:   andreas.friebe(at)remove-this.uni-wuerzburg.de
Website link

Date of birth     April 26, 1967

Curriculum Vitae

1988-1991Undergraduate Studies: Biology,  Universität Freiburg
- B.A. in Biology (Vordiplom)
1991-1993Graduate Studies: 'Programme of Molecular and Cellular Biology', University of Massachusetts, Amherst / USA (Prof. Ed W. Westhead)
- M.Sc. in Molecular and Cellular Biology
1993-1996PhD Studies, Pharmakologisches Institut, Freie Universität Berlin (Prof. Günter Schultz)
- PhD in Biology (Dr. rer. nat.)
1996-1999Post-Doc, Institut für Pharmakologie und Toxikologie, Freie Universität Berlin (Prof. Doris Koesling)
1999-2004Research Associate (C1, C2), Institut für Pharmakologie und Toxikologie, Ruhr-Universität Bochum (Prof. Doris Koesling)
- Habilitation (2003)
2004-2009Assistant Professor of Pharmacology (C2), Ruhr-Universität Bochum
2009 - presentProfessor of Physiology (W2), Physiologisches Institut, Universität Würzburg

Selected publications

1.    Straubinger J, Schottle V, Bork N, Subramanian H, Dunnes S, Russwurm M, Gawaz M, Friebe A, Nemer M, Nikolaev VO, Lukowski R. Sildenafil does not prevent heart hypertrophy and fibrosis induced by cardiomyocyte AT1R signaling. J Pharmacol Exp Ther. 2015;354:406-16 [pubmed]

2.    Hoffmann LS, Etzrodt J, Willkomm L, Sanyal A, Scheja L, Fischer AW, Stasch JP, Bloch W, Friebe A, Heeren J, Pfeifer A. Stimulation of soluble guanylyl cyclase protects against obesity by recruiting brown adipose tissue. Nat Commun. 2015;26;6:7235 [pubmed]

3.    Bettaga N, Jäger R, Dünnes S, Groneberg D, Friebe A. Cell-specific impact of nitric oxide-dependent guanylyl cyclase on arteriogenesis and angiogenesis in mice. Angiogenesis. 2015;18:245-54 [pubmed]

4.    Groneberg D, Zizer E, Lies B, Seidler B, Saur D, Wagner M, Friebe A. Dominant role of interstitial cells of Cajal in nitrergic relaxation of murine lower oesophageal sphincter. J Physiol. 2015;593:403-14 [pubmed]

5.    Beyer C, Zenzmaier C, Palumbo-Zerr K, Mancuso R, Distler A, Dees C, Zerr P, Huang J, Maier C, Pachowsky ML, Friebe A, Sandner P, Distler O, Schett G, Berger P, Distler JH. Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling. Ann Rheum Dis. 2014;74:1408-16 [pubmed]

6.    Groneberg D, Lies B, König P, Jäger R, Seidler B, Klein S, Saur D, Friebe A. Cell-Specific deletion of nitric oxide-sensitive guanylyl cyclase reveals a dual pathway for nitrergic neuromuscular transmission in the murine fundus. Gastroenterology. 2013;145:188-96 [pubmed]

7.    Groneberg D, Lies B, König P, Jäger R, Friebe A. Preserved fertility despite erectile dysfunction in mice lacking the nitric oxide receptor. J Physiol. 2013;591:491-502 [pubmed]

8.    Groneberg D, König P, Koesling D, Friebe A. Nitric oxide-sensitive guanylyl cyclase is dispensable for nitrergic signaling and gut motility in mouse intestinal smooth muscle. Gastroenterology. 2011;140:1608-17 [pubmed]

9.    Groneberg D, König P, Wirth A, Offermanns S, Koesling D, Friebe A. Smooth muscle-specific deletion of nitric oxide-sensitive guanylyl cyclase is sufficient to induce hypertension in mice. Circulation. 2010;121:401-9 [pubmed]

10.  Friebe A, Mergia E, Dangel O, Lange A, Koesling D. Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase. Proc Natl Acad Sci U S A. 2007;104:7699-704 [pubmed]