Prof. Dr. Robert Feil

Universität Tübingen
IFIB -€“ Interfakultäres Institut für Biochemie
Auf der Morgenstelle 34
72076 Tübingen


Tel.: 07071-29-73350
E-Mail: robert.feil(at)remove-this.uni-tuebingen.de
Website link

Date of birth    April 21, 1966

Curriculum Vitae

1985-1991Diploma in Biology, TU München
1991Diploma thesis "Characterization of a cloned starch-converting enzyme of Thermotoga maritima", TU München, supervisor: Prof. Dr. K.H. Schleifer
1991-1995PhD "High-level expression of cGMP-dependent protein kinase using prokaryotic and eukaryotic expression systems", TU München, supervisor: Prof. Dr. F. Hofmann (summa cum laude)
1995-1997Postdoc with Prof. Dr. P. Chambon, IGBMC - Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg, France ("Conditional mutagenesis in mice"), supported by EMBO and HFSPO long-term fellowships
1998-2004Group leader (C1, C2) at the Institut für Pharmakologie und Toxikologie, TU München ('Genetic dissection of cGMP signalling in transgenic mice')
2003Habilitation und venia legendi in "Pharmakologie und Toxikologie"
2005Professor of Biochemistry (C3), University of Tübingen
2005Decline of an offer as a W2/C3-Professor for Molekulare Ernährungsmedizin at the TU München
2009Decline of an offer of a W3-Professur for Biochemie at the Universität Halle-Wittenberg
since 2009Professor of Biochemistry (W3), University of Tübingen
2009-2010Dean of studies for Biochemistry
2012-2013Visiting Professor at Massachusetts General Hospital/Harvard Medical School, Boston, USA
2013 - presentSpeaker of the DFG Research Unit "cGMP Signalling in Cell Growth and Survival" (FOR 2060)
2014 - presentSpeaker / Deputy Speaker of the Department of Pharmacy and Biochemistry of the Faculty of Science, University of Tübingen

Selected publications

1.    Feil S, Fehrenbacher B, Lukowski R, Essmann F, Schulze-Osthoff K, Schaller M, Feil R. Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis. Circ Res. 2014;115:662-7 [pubmed]

2.    Kröner C, Thunemann M, Vollmer S, Kinzer M, Feil R, Richert C. Endless: A purine-binding RNA motif that can be expressed in cells. Angew Chem Int Ed Engl. 2014;53:9189-202 [pubmed]

3.    Thunemann M, Wen L, Hillenbrand M, Vachaviolos A, Feil S, Ott T, Han X, Fukumura D, Jain RK, Russwurm M, de Wit C, Feil R. Transgenic mice for cGMP imaging. Circ Res 2013;113:365-71 [pubmed]

4.     Jaumann M, Dettling J, Gubelt M, Zimmermann U, Gerling A, Paquet-Durand F, Feil S, Wolpert S, Franz C, Varakina K, Xiong H, Brandt N, Kuhn S, Geisler HS, Rohbock K, Ruth P, Schlossmann J, Hütter J, Sandner P, Feil R, Engel J, Knipper M, Rüttiger L. cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. Nat Med. 2012;18:252-9 [pubmed]

5.     Lutz SZ, Hennige AM, Feil S, Peter A, Gerling A, Machann J, Kröber SM, Rath M, Schürmann A, Weigert C, Häring HU, Feil R. Genetic ablation of cGMP-dependent protein kinase type I causes liver inflammation and fasting hyperglycemia. Diabetes 2011;60:1566-76 [pubmed]

6.     Katajisto P, Vaahtomeri K, Ekman N, Ventelä E, Ristimäki A, Bardeesy N, Feil R, DePinho RA, Mäkelä TP. LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis. Nat Genet. 2008;40:455-9 [pubmed] 

7.    Wolfsgruber W, Feil S, Brummer S, Kuppinger O, Hofmann F, Feil R. A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells. Proc Natl Acad Sci U S A. 2003;100:13519-24 [pubmed]

8.     Li Z, Xi X, Gu M, Feil R, Ye RD, Eigenthaler M, Hofmann F, Du X. A stimulatory role for cGMP-dependent protein kinase in platelet activation. Cell. 2003;112:77-86 [pubmed]

9.    Wegener JW, Nawrath H, Wolfsgruber W, Kühbandner S, Werner C, Hofmann F, Feil R. cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardium. Circ Res. 2002;90:18-20 [pubmed]

10.  Feil R, Brocard J, Mascrez B, LeMeur M, Metzger D, Chambon P. Ligand-activated site-specific recombination in mice. Proc Natl Acad Sci U S A. 1996;93:10887-90 [pubmed]