Dr. Susanne Feil

Universität Tübingen
IFIB -€“ Interfakultäres Institut für Biochemie
Auf der Morgenstelle 34
72076 Tübingen


Tel.: 07071-29-72458
E-Mail: susanne.feil(at)remove-this.uni-tuebingen.de
Website link

Date of birth    February 03, 1966

Curriculum Vitae

 1985-1992Certified riding instructor and horse master (Pferdewirtschaftsmeister, Schwerpunkt Reiten)
1992-1997Diploma in Agricultural Sciences (Dipl.-Ing.Agr.Univ.), TU München
1997-2001PhD (Dr. rer. nat.) "Inducible Cre-mediated recombination in smooth muscle of mice", TU München, supervisor: Prof. Dr. F. Hofmann (summa cum laude)
2001Award for the best PhD thesis given by Bund der Freunde der TU München e.V.
2001-2006Postdoc with Prof. Dr. F. Hofmann, Institut für Pharmakologie und Toxikologie, TU München ('Conditional mutagenesis in mice')
2006-presentSenior Scientist at Interfakultäres Institut für Biochemie (IFIB), University of Tübingen
2008Maternity leave (birth of Anna Feil, December 2007)
2009Re-entry into scientific work at Interfakultäres Institut für Biochemie (IFIB), University of Tübingen
2010Maternity leave (birth of Lena Feil, June 2010)
2013Re-entry into scientific work at Interfakultäres Institut für Biochemie (IFIB), University of Tübingen

Selected publications

1.    Feil S, Fehrenbacher B, Lukowski R, Essmann F, Schulze-Osthoff K, Schaller M, Feil R. Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis. Circ Res. 2014;115:662-7 [pubmed]

2.    Thunemann M, Wen L, Hillenbrand M, Vachaviolos A, Feil S, Ott T, Han X, Fukumura D, Jain RK, Russwurm M, de Wit C, Feil R. Transgenic mice for cGMP imaging. Circ Res 2013;113:365-71 [pubmed]

3.     Jaumann M, Dettling J, Gubelt M, Zimmermann U, Gerling A, Paquet-Durand F, Feil S, Wolpert S, Franz C, Varakina K, Xiong H, Brandt N, Kuhn S, Geisler HS, Rohbock K, Ruth P, Schlossmann J, Hütter J, Sandner P, Feil R, Engel J, Knipper M, Rüttiger L. cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. Nat Med. 2012;18:252-9 [pubmed]

4.    Luo C, Gangadharan V, Bali K, Xie R, Agarwal N, Kurejova M, Tappe-Theodor A, Tegeder I, Feil S, Lwein G, Polgar E, Todd AJ, Schlossmann J, Hofmann F, Liu D, Hu S, Feil R, Kuner T, Kuner R. Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity. PLoS Biol. 2011;10:e1001283 [pubmed]

5.    *Föller M, *Feil S, Ghoreschi K, Koka S, Gerling A, Thunemann M, Hofmann F, Schuler B, Vogel J, Pichler B, Kasinathan RS, Nicolay JP, Huber SM, Lang F, Feil R. Anemia and splenomegaly in cGKI-deficient mice. Proc Natl Acad Sci U S A. 2008;105:6771-6 (*equal contribution) [pubmed]

6.    Weber S, Bernhard D, Lukowski R, Weinmeister P, Wörner R, Wegener JW, Valtcheva N, Feil S, Schlossman J, Hofmann F, Feil R. Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozyme. Circ Res. 2007;101:1096-103 [pubmed]

7.    Feil S, Hofmann F, Feil R. SM22 alpha modulates vascular smooth muscle cell phenotype during atherogenesis. Circ Res. 2004;94:863-5 [pubmed]

8.    *Wolfsgruber W, *Feil S, Brummer S, Kuppinger O, Hofmann F, Feil R. A proatherogenic role for cGMP-dependent protein kinase in vascular smooth muscle cells. Proc Natl Acad Sci U S A. 2003;100:13519-24 (*equal contribution) [pubmed]

9.    Wegener JW, Nawrath H, Wolfsgruber W, Kühbandner S, Werner C, Hofmann F, Feil R. cGMP-dependent protein kinase I mediates the negative inotropic effect of cGMP in the murine myocardium. Circ Res. 2002;90:18-20 [pubmed]

10.  Kühbandner S, Brummer S, Metzger D, Chambon P, Hofmann F, Feil R. Temporally controlled somatic mutagenesis in smooth muscle. Genesis. 2000;28:15-22 [pubmed]