Prof. Dr. Dr. Achim Schmidtko

Goethe-Universität Frankfurt am Main
Pharmakologisches Institut für Naturwissenschaftler
Fachbereich Biochemie, Chemie und Pharmazie
Max-von-Laue-Str. 9
60438 Frankfurt am Main


Tel.:     069-798-29373
Fax:     069-798-29374
E-Mail: schmidtko(at)remove-this.em.uni-frankfurt.de
Website link

Date of birth July 08, 1972

Curriculum Vitae

1992-1998Studies in Pharmacy, Universität Frankfurt, Approbation (Apotheker) 1998
1998-2004Studies in Medicine, Universität Frankfurt, Approbation (Arzt) 2004
2000-2004PhD thesis 'Mechanismen der Stickstoffmonoxid-vermittelten Nozizeption', Universität Frankfurt
Supervisor: Prof. Dr. Dr. G. Geisslinger (magna cum laude)
2004-2012Postdoc with Prof. Dr. Dr. G. Geisslinger at the Institut für Klinische Pharmakologie, Universität Frankfurt
2006-2008MD thesis 'Cysteine-Rich Protein 2: A Substrate of cGMP-Dependent Protein Kinase I in Nociceptive Processing', Universität Frankfurt
Supervisor: Prof. Dr. Dr. G. Geisslinger (summa cum laude)
2010Habilitation and venia legendi in 'Clinical Pharmacology'
Title of the habilitation thesis: 'cGMP-abhängige Mechanismen der Schmerzsensibilisierung'
2010Medical specialist (Facharzt) in Clinical Pharmacology
2012-2016Full Professor and Chair, Pharmacology and Toxicology, Universität Witten/Herdecke
2013Medical specialist (Facharzt) in Pharmacology and Toxicology
Since 2016Professor (W3) of Pharmacology, Fachbereich Biochemie, Chemie und Pharmazie, Universität Frankfurt

Selected publications

1.    Lu R, Bausch A, Kallenborn-Gerhardt W, Stoetzer C, Debruin N, Ruth P, Geisslinger G, Leffler A, Lukowski R, Schmidtko A. Slack channels expressed in sensory neurons control neuropathic pain in mice. J Neurosci. 2015;35:1125-35 [pubmed]

2.    Lorenz JE, Kallenborn-Gerhardt W, Lu R, Syhr KM, Eaton P, Geisslinger G, Schmidtko A. Oxidant-induced activation of cGMP-dependent protein kinase Iα mediates neuropathic pain after peripheral nerve injury. Antioxid Redox Signal. 2014;21:1504-15 [pubmed]

3.    Kallenborn-Gerhardt W, Lu R, Bothe A, Thomas D, Schlaudraff J, Lorenz JE, Lippold N, Real CI, Ferreirós N, Geisslinger G, Del Turco D, Schmidtko A. Phosphodiesterase 2A localized in the spinal cord contributes to inflammatory pain processing. Anesthesiology. 2014;121:372-82 [pubmed]

4.    Lu R, Lukowski R, Sausbier M, Zhang DD, Sisignano M, Schuh CD, Kuner R, Ruth P, Geisslinger G, Schmidtko A. BKCa channels expressed in sensory neurons modulate inflammatory pain in mice. Pain. 2014;155:556-65 [pubmed]

5.    Kallenborn-Gerhardt W, Lu R, Syhr KM, Heidler J, von Melchner H, Geisslinger G, Bangsow T, Schmidtko A. Antioxidant activity of Sestrin 2 controls neuropathic pain after peripheral nerve injury. Antioxid Redox Signal. 2013;19:2013-23 [pubmed]

6.    Kallenborn-Gerhardt W, Schröder K, Del Turco D, Lu R, Kynast K, Kosowski J, Niederberger E, Shah AM, Brandes RP, Geisslinger G, Schmidtko A. NADPH oxidase-4 maintains neuropathic pain after peripheral nerve injury. J Neurosci. 2012;32:10136-45 [pubmed]

7.    Heine S, Michalakis S, Kallenborn-Gerhardt W, Lu R, Lim H, Weiland J, Del Turco D, Deller T, Tegeder I, Biel M, Geisslinger G, Schmidtko A. CNGA3: A target of spinal NO/cGMP signaling and modulator of inflammatory pain hypersensitivity. J Neurosci. 2011;31:11184-92 [pubmed]

8.    Schmidtko A, Lötsch J, Freynhagen R, Geisslinger G. Ziconotide for treatment of severe chronic pain. Lancet. 2010;375:1569-77 [pubmed]

9.    Schmidtko A, Gao W, König P, Heine S, Motterlini R, Ruth P, Schlossmann J, Koesling D, Niederberger E, Tegeder I, Friebe A, Geisslinger G. cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. J Neurosci. 2008;28:8568-76 [pubmed]

10.  Schmidtko A, Gao W, Sausbier M, Rauhmeier I, Sausbier U, Niederberger E, Scholich K, Huber A, Neuhuber W, Allescher HD, Hofmann F, Tegeder I, Ruth P, Geisslinger G. Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain. J Neurosci. 2008;28:1320-30 [pubmed]