Selected collaborative publications 2006-2012

1.    Engel J, Braig C, Rüttiger L, Kuhn S, Zimmermann U, Blin N, Sausbier M, Kalbacher H, Mänkner S, Rohbock K, Ruth P, Winter H, Knipper M. Two classes of outer hair cells along the tonotopic axis of the cochlea. Neuroscience. 2006;143:837-49 [pubmed] [Project 5 and Project 8]

2.    Mergia E, Friebe A, Dangel O, Russwurm M, Koesling D. Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system. J Clin Invest. 2006;116:1731-7 [pubmed] [Project 2 and Project 3]

3.    Friebe A, Mergia E, Dangel O, Lange A, Koesling D. Fatal gastrointestinal obstruction and hypertension in mice lacking nitric oxide-sensitive guanylyl cyclase. Proc Natl Acad Sci U S A. 2007;104:7699-704 [pubmed][Project 2 and Project 3]

4.    Haghikia A, Mergia E, Friebe A, Eysel UT, Koesling D, Mittmann T. Long-term potentiation in the visual cortex requires both nitric oxide receptor guanylyl cyclases. J Neurosci. 2007;27:818-23 [pubmed[Project 2 and Project 3]

5.    Schmidt H, Stonkute A, Juttner R, Schaffer S, Buttgereit J, Feil R, Hofmann F, Rathjen FG. The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord. J Cell Biol. 2007;179:331-40 [pubmed] [Project 1 and Project 6]

6.    Weber S, Bernhard D, Lukowski R, Weinmeister P, Worner R, Wegener JW, Valtcheva N, Feil S, Schlossmann J, Hofmann F, Feil R. Rescue of cGMP kinase I knockout mice by smooth muscle specific expression of either isozyme. Circ Res. 2007;101:1096-103 [pubmed] [Project 1 and Project 5]

7.    Schmidtko A, Gao W, König P, Heine S, Motterlini R, Ruth P, Schlossmann J, Koesling D, Niederberger E, Tegeder I, Friebe A, Geisslinger G. cGMP produced by NO-sensitive guanylyl cyclase essentially contributes to inflammatory and neuropathic pain by using targets different from cGMP-dependent protein kinase I. J Neurosci. 2008;28:8568-76 [pubmed] [Project 2] [Project 3] [Project 5] [Project 10

8.    Weinmeister P, Lukowski R, Linder S, Traidl-Hoffmann C, Hengst L, Hofmann F, Feil R. Cyclic guanosine monophosphate-dependent protein kinase I promotes adhesion of primary vascular smooth muscle cells. Mol Biol Cell. 2008;19:4434-41 [pubmed] [Project 1 and Project 5]

9.    Schmidtko A, Gao W, Sausbier M, Rauhmeier I, Sausbier U, Niederberger E, Scholich K, Huber A, Neuhuber W, Allescher HD, Hofmann F, Tegeder I, Ruth P, Geisslinger G. Cysteine-rich protein 2, a novel downstream effector of cGMP/cGMP-dependent protein kinase I-mediated persistent inflammatory pain. J Neurosci. 2008;28:1320-30 [pubmed] [Project 5] [Project 10]

10.  Lukowski R, Weinmeister P, Bernhard D, Feil S, Gotthardt M, Herz J, Massberg S, Zernecke A, Weber C, Hofmann F, Feil R. Role of smooth muscle cGMP/cGKI signaling in murine vascular restenosis. Arterioscler Thromb Vasc Biol. 2008;28:1244-50 [pubmed] [Project 1 and Project 5]

11.  Schmidt H, Stonkute A, Jüttner R, Koesling D, Friebe A, Rathjen FG. C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons. Proc Natl Acad Sci U S A. 2009;106:16847-52 [pubmed] [Project 2, Project 3 and Project 6]

12.  Tedeschi A, Nguyen T, Steele SU, Feil S, Naumann U, Feil R, Di Giovanni S. The tumor suppressor p53 transcriptionally regulates cGKI expression during neuronal maturation and is required for cGMP-dependent growth cone collapse. J Neurosci. 2009;29:15155-60 [pubmed] [Project 1 and Project 7]

13.  Groneberg D, König P, Wirth A, Offermanns S, Koesling D, Friebe A. Smooth muscle-specific deletion of nitric oxide-sensitive guanylyl cyclase is sufficient to induce hypertension in mice. Circulation. 2010;121:401-9 [pubmed] [Project 2 and Project 3]

14.  Dangel O, Mergia E, Karlisch K, Groneberg D, Koesling D, Friebe A. Nitric oxide-sensitive guanylyl cyclase is the only nitric oxide receptor mediating platelet inhibition. J Thromb Haemost. 2010;8:1343-52 [pubmed] [Project 2 and Project 3]

15.  Klaiber M, Dankworth B, Kruse M, Hartmann M, Nikolaev VO, Yang R, Völker K, Gaߟner K, Oberwinkler H, Feil R, Freichel M, Groschner K, Skryabin BV, Frantz S, Birnbaumer L, Pongs O, Kuhn M. A cardiac pathway of cyclic GMP-independent signaling of guanylyl cyclase A, the receptor for atrial natriuretic peptide. Proc Natl Acad Sci U S A. 2011;108:18500-5 [pubmed] [Project 1 and Project 4]

16.  Groneberg D, König P, Koesling DFriebe A. Nitric oxide-sensitive guanylyl cyclase is dispensable for nitrergic signaling and gut motility in mouse intestinal smooth muscle. Gastroenterology. 2011;140:1608-17 [pubmed] [Project 2 and Project 3]

17.  Leiss V, Friebe A, Welling A, Hofmann F, Lukowski R. Cyclic GMP kinase I modulates glucagon release from pancreatic α-cells. Diabetes. 2011;60:148-56 [pubmed] [Project 3 and Project 5]

18.  Jaumann M, Dettling J, Gubelt M, Zimmermann U, Gerling A, Paquet-Durand F, Feil S, Wolpert S, Franz C, Varakina K, Xiong H, Brandt N, Kuhn S, Geisler H, Rohbock K, Ruth P, Schlossmann J, Hütter J, Sandner P, Feil R, Engel J, Knipper M, Rüttiger L. cGMP-cGKI signaling and PDE5 inhibition shelter cochlear hair cells and hearing function. Nat Med. 2012;18:252-9 [pubmed] [Project 1, Project 5, Project 8 and Project 9]

19.  Tanimoto N, Sothilingam V, Euler T, Ruth P, Seeliger MW, Schubert T. BK channels mediate pathway-specific modulation of visual signals in the in vivo mouse retina. J Neurosci. 2012;32:4861-6 [pubmed] [Project 5 and Project 9]

20.  Kurt S, Sausbier M, Rüttiger L, Brandt N, Moeller CK, Kindler J, Sausbier U, Zimmermann U, van Straaten H, Neuhuber W, Engel J, Knipper M, Ruth P, Schulze H. Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing. FASEB J. 2012;179:331-40 [pubmed] [Project 5 and Project 8]