Selected publications during the FOR 2060 funding period 2013-2021

2021 Publications

  1. Berisha F, Götz KR, Wegener JW, Brandenburg S, Subramanian H, Molina CE, Rüffer A, Petersen J, Bernhardt A, Girdauskas E, Jungen C, Pape U, Kraft AE, Warnke S, Lindner D, Westermann D, Blankenberg S, Meyer C, Hasenfuß G, Lehnart SE, Nikolaev VO. cAMP Imaging at ryanodine receptors reveals β2-adrenoceptor driven arrhythmias. Circ Res. 2021 Jun 25;129(1):81-94. [pubmed] [Project 4]
  2. Nording H, Baron L, Haberthür D, Emschermann F, Mezger M, Sauter M, Sauter R, Patzelt J, Knoepp K, Nording A, Meusel M, Meyer-Saraei R, Hlushchuk R, Sedding D, Borst O, Eitel I, Karsten CM, Feil R, Pichler B, Erdmann J, Verschoor A, Chavakis E, Chavakis T, von Hundelshausen P, Köhl J, Gawaz M, Langer HF. The C5a/C5a receptor 1 axis controls tissue neovascularization through CXCL4 release from platelets. Nat Commun. 2021 Jun 7;12(1):3352. [pubmed] [Project Z]
  3. Stehle D, Xu MZ, Schomber T, Hahn MG, Schweda F, Feil S, Kraehling JR, Eitner F, Patzak A, Sandner P, Feil R, Bénardeau A. Novel soluble guanylyl cyclase activators increase glomerular cGMP, induce vasodilation and improve blood flow in the murine kidney. Br J Pharmacol. 2021 Jun 7. [pubmed] [Project 1] [Project Z]
  4. Lukowski R, Cruz Santos M, Kuret A, Ruth P. cGMP and mitochondrial K+ channels - Compartmentalized but closely connected in cardioprotection. Br J Pharmacol. 2021 May 15. Review [pubmed] [Project 5]
  5. Manfra O, Calamera G, Froese A, Arunthavarajah D, Surdo NC, Meier S, Melleby AO, Aasrum M, Aronsen JM, Nikolaev VO, Zaccolo M, Moltzau LR, Levy FO, Andressen KW. CNP regulates cardiac contractility and increases cGMP near both SERCA and TnI - difference from BNP visualized by targeted cGMP biosensors. Cardiovasc Res. 2021 May 10:cvab167. [pubmed] [Project 4]
  6. Schmidt H, Böttcher A, Gross T, Schmidtko A. cGMP signalling in dorsal root ganglia and the spinal cord: Various functions in development and adulthood. Br J Pharmacol. 2021 May 3. Review [pubmed] [Project 6] [Project 10]
  7. Feil R, Lehners M, Stehle D, Feil S. Visualising and understanding cGMP signals in the cardiovascular system. Br J Pharmacol. 2021 Apr 20. Review [pubmed] [Project 1] [Project Z]
  8. Tchernychev B, Li H, Lee SK, Gao X, Ramanarasimhaiah R, Liu G, Hall KC, Bernier SG, Jones JE, Feil S, Feil R, Buys ES, Graul RM, Frenette PS, Masferrer JL. Olinciguat, a stimulator of soluble guanylyl cyclase, attenuates inflammation, vaso-occlusion and nephropathy in mouse models of sickle cell disease. Br J Pharmacol. 2021 Apr 17. [pubmed] [Project 1]
  9. Marchetta P, Rüttiger L, Hobbs AJ, Singer W, Knipper M. The role of cGMP signalling in auditory processing in health and disease. Br J Pharmacol. 2021 Mar 26. Review [pubmed] [Project 8]
  10. Tikoo S, Jain R, Tomasetig F, On K, Martinez B, Heu C, Stehle D, Obeidy P, Guo D, Vincent JN, Cook AJL, Roediger B, Feil R, Whan RM, Weninger W. Amelanotic B16-F10 melanoma compatible with advanced three-dimensional imaging modalities. J Invest Dermatol. 2021 Mar 4:S0022-202X(21)00156-1. [pubmed] [Project Z]
  11. Zink J, Frye M, Frömel T, Carlantoni C, John D, Schreier D, Weigert A, Laban H, Salinas G, Stingl H, Günther L, Popp R, Hu J, Vanhollebeke B, Schmidt H, Acker-Palmer A, Renné T, Fleming I, Benz PM. EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis. EMBO Rep. 2021 Feb 3;22(2):e48961. [pubmed] [Project 6]
  12. Lu R, Metzner K, Zhou F, Flauaus C, Balzulat A, Engel P, Petersen J, Ehinger R, Bausch A, Ruth P, Lukowski R, Schmidtko A. Functional coupling of slack channels and P2X3 receptors contributes to neuropathic pain processing. Int J Mol Sci. 2021 Jan 2;22(1):405. [pubmed] [Project 5] [Project 10]
  13. Krämer MS, Feil R, Schmidt H. Analysis of gene expression using lacZ reporter mouse lines. Methods Mol Biol. 2021;2224:29-45. [pubmed] [Project 1] [Project 6]
  14. Bork NI, Kuret A, Cruz Santos M, Molina CE, Reiter B, Reichenspurner H, Friebe A, Skryabin BV, Rozhdestvensky TS, Kuhn M, Lukowski R, Nikolaev VO. Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia. Redox Biol.; 48:102179. doi: 10.1016/j.redox. 2021.102179. Epub ahead of print. [pubmed] [Project 3] [Project 4] [Project 5]
  15. Matt L, Pham T, Skrabak D, Hoffmann F, Eckert P, Yin J, Gisevius M, Ehinger R, Bausch A, Ueffing M, Boldt K, Ruth P, Lukowski R. The Na+-activated K+ channel Slack contributes to synaptic development and plasticity. Cell Mol Life Sci. 2021; doi: 10.1007/s00018-021-03953-0. Epub ahead of print. [pubmed] [Project 5]
  16. Längst N, Adler J, Schweigert O, Kleusberg F, Cruz Santos M, Knauer A, Sausbier M, Zeller T, Ruth P, Lukowski R. Cyclic GMP-dependent regulation of vascular tone and blood pressure involves cysteine-rich LIM-only protein 4 (CRP4). Int J Mol Sci. 2021; 22(18):9925. doi: 10.3390/ijms22189925. [pubmed] [Project 5]

2020 Publications

  1. Friebe A, Englert N. NO-sensitive guanylyl cyclase in the lung. Br J Pharmacol. 2020 Dec 17. [pubmed] [Project 3]
  2. Li X, Li J, Martinez EC, Froese A, Passariello CL, Henshaw K, Rusconi F, Li Y, Yu Q, Thakur H, Nikolaev VO, Kapiloff MS. Calcineurin Aβ-specific anchoring confers isoform-specific compartmentation and function in pathological cardiac myocyte hypertrophy. Circulation. 2020 Sep 8;142(10):948-962. [pubmed] [Project 4]
  3. Mohr CJ, Schroth W, Mürdter TE, Gross D, Maier S, Stegen B, Dragoi A, Steudel FA, Stehling S, Hoppe R, Madden S, Ruth P, Huber SM, Brauch H, Lukowski R. Subunits of BK channels promote breast cancer development and modulate responses to endocrine treatment in preclinical models. Br J Pharmacol. 2020 May 28. [pubmed] [Project 5]
  4. Marchetta P, Möhrle D, Eckert P, Reimann K, Wolter S, Tolone A, Lang I, Wolters M, Feil R, Engel J, Paquet-Durand F, Kuhn M, Knipper M, Rüttiger L. Guanylyl cyclase A/cGMP signaling slows hidden, age- and acoustic trauma-induced hearing loss. Front Aging Neurosci. 2020 Apr 9;12:83. [pubmed] [Project 1] [Project Z] [Project 8]
  5. Dumoulin A, Schmidt H, Rathjen FG. Sensory neurons: The formation of T-shaped branches is dependent on a cGMP-dependent signaling cascade. Neuroscientist. 2020 Apr 23:1073858420913844. Review [pubmed] [Project 6]
  6. Schobesberger S, Wright PT, Poulet C, Sanchez Alonso Mardones JL, Mansfield C, Friebe A, Harding SE, Balligand JL, Nikolaev VO, Gorelik J. β3-Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes. Elife. 2020 Mar 31;9. pii: e52221. [pubmed] [Project 3] [Project 4]
  7. Friebe A, Sandner P, Schmidtko A. cGMP: a unique 2nd messenger molecule - recent developments in cGMP research and development. Naunyn Schmiedebergs Arch Pharmacol. 2020 Feb;393(2):287-302. Review  [pubmed] [Project 3] [Project 10]
  8. Cuello F, Nikolaev VO. Cardiac cGMP signaling in health and disease: Location, location, location. J Cardiovasc Pharmacol. 2020 May;75(5):399-409. Review  [pubmed] [Project 4]
  9. Adler J, Kuret A, Längst N, Lukowski R. Targets of cGMP/cGKI in cardiac myocytes. J Cardiovasc Pharmacol. 2020 Mar 10. Review [pubmed] [Project 5]
  10. Kallenborn-Gerhardt W, Metzner K, Lu R, Petersen J, Kuth MS, Heine S, Drees O, Paul M, Becirovic E, Kennel L, Flauaus C, Gross T, Wack G, Hohmann SW, Nemirovski D, Del Turco D, Biel M, Geisslinger G, Michalakis S, Schmidtko A. Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1. Neuropharmacology. 2020 Apr 6;171:108087. [pubmed] [Project 10]

2019 Publications

  1. Shvedova M, Litvak MM, Roberts JD Jr, Fukumura D, Suzuki T, Şencan İ, Li G, Reventun P, Buys ES, Kim HH, Sakadžić S, Ayata C, Huang PL, Feil R, Atochin DN. cGMP-dependent protein kinase I in vascular smooth muscle cells improves ischemic stroke outcome in mice. J Cereb Blood Flow Metab. 2019 Aug 18:271678X19870583. [pubmed] [Project 1] [Project Z]
  2. Fröhlich H, Kollmeyer ML, Linz VC, Stuhlinger M, Groneberg D, Reigl A, Zizer E, Friebe A, Niesler B, Rappold G. Gastrointestinal dysfunction in autism displayed by altered motility and achalasia in Foxp1 +/- mice. PNAS 2019;116(44): 22237-22245. [pubmed] [Project 3]
  3. Beck K, Voussen B, Reigl A, Vincent AD, Parsons SP, Huizinga JD, Friebe A. Cell-specific effects of nitric oxide on the efficiency and frequency of long distance contractions in murine colon. Neurogastroenterol Motil. 2019;31(6):e13589. [pubmed] [Project 3]
  4. Petersen J, Mergia E, Kennel L, Drees O, Steubing RD, Real CI, Kallenborn-Gerhardt W, Lu R, Friebe A, Koesling D, Schmidtko A. Distinct functions of soluble guanylyl cyclase isoforms NO-GC1 and NO-GC2 in inflammatory and neuropathic pain processing. Pain 2019;160(3):607-618 [pubmed] [Project 3] [Project 10]
  5. Bork NI, Molina CE, Nikolaev VO. cGMP signalling in cardiomyocyte microdomains. Biochem Soc Trans. 2019;47(5):1327-1339. Review [pubmed] [Project 4]
  6. Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O. Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death. Nature. 2019;569(7755):236-240. [pubmed] [Project 4]
  7. Bastug-Özel Z, Wright PT, Kraft AE, Pavlovic D, Howie J, Froese A, Fuller W, Gorelik J, Shattock MJ, Nikolaev VO. Heart failure leads to altered β2-adrenoceptor/cyclic adenosine monophosphate dynamics in the sarcolemmal phospholemman/Na,K ATPase microdomain. Cardiovasc Res. 2019;115(3):546-555. [pubmed] [Project 4]
  8. Mohr CJ, Gross D, Sezgin EC, Steudel FA, Ruth P, Huber SM, Lukowski R. KCa3.1 channels confer radioresistance to breast cancer cells. Cancers (Basel). 2019 Sep 1;11(9). pii: E1285. [pubmed] [Project 5]
  9. Schmidt H, Fritzsch B. Npr2 null mutants show initial overshooting followed by reduction of spiral ganglion axon projections combined with near-normal cochleotopic projection. Cell Tissue Res. 2019;378(1):15-32. [pubmed] [Project 6]
  10. Möhrle D, Hofmeier B, Amend M, Wolpert S, Ni K, Bing D, Klose U, Pichler B, Knipper M, Rüttiger L. Enhanced central neural gain compensates acoustic trauma-induced cochlear impairment, but unlikely correlates with tinnitus and hyperacusis. Neuroscience. 2019;407:146-169. [pubmed] [Project 8]

2018 Publications

  1. Wen L, Feil S, Wolters M, Thunemann M, Regler F, Schmidt K, Friebe A, Olbrich M, Langer H, Gawaz M, de Wit C, Feil R. A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis. Nat Commun. 2018;9:4301. [pubmed] [Project 1] [Project 3] [Project Z] [News Article & Press Release]
  2. Grundy L, Harrington AM, Castro J, Garcia-Caraballo S, Deiteren A, Maddern J, Rychkov GY, Ge P, Peters S, Feil R, Miller P, Ghetti A, Hannig G, Kurtz CB, Silos-Santiago I, Brierley SM. Chronic linaclotide treatment reduces colitis-induced neuroplasticity and reverses persistent bladder dysfunction. JCI Insight. 2018;3, pii: 121841. [pubmed] [Project 1] [Project Z]
  3. Schmidt H, Dickey DM, Dumoulin A, Octave M, Robinson JW, Kühn R, Feil R, Potter LR, Rathjen FG. Regulation of the natriuretic peptide receptor 2 (Npr2) by phosphorylation of juxtamembrane serine and threonine residues is essential for bifurcation of sensory axons. J Neurosci. 2018;pii: 0495-18. [pubmed] [Project 1] [Project 6]
  4. Zalucki O, Harris L, Harvey TJ, Harkins D, Widagdo J, Oishi S, Matuzelski E, Yong XLH, Schmidt H, Anggono V, Burne THJ, Gronostajski RM, Piper M. NFIX-mediated inhibition of neuroblast branching regulates migration within the adult mouse ventricular-subventricular zone. Cereb Cortex. 2018; doi: 10.1093/cercor/bhy233. [pubmed] [Project 6]
  5. Peters S, Paolillo M, Mergia E, Koesling D, Kennel L, Schmidtko A, Russwurm M, Feil R. cGMP imaging in brain slices reveals brain region-specific activity of NO-sensitive guanylyl cyclases (NO-GCs) and NO-GC stimulators. Int J Mol Sci. 2018;19 pii: E2313 [pubmed] [Project 1] [Project 10]
  6. Wolter S, Möhrle D, Schmidt H, Pfeiffer S, Zelle D, Eckert P, Krämer M, Feil R, Pilz PK, Knipper M, Rüttiger L. GC-B deficient mice with axon bifurcation loss exhibit compromised auditory processing. Front Neural Circuits. 2018 Aug 29;12:65. [pubmed] [Project 1] [Project 6] [Project 8]
  7. Paolillo M, Peters S, Schramm A, Schlossmann J, Feil R. Real-time imaging reveals augmentation of glutamate-induced Ca2+ transients by the NO-cGMP pathway in cerebellar granule neurons. Int J Mol Sci. 2018;19 pii: E2185. [pubmed] [Project 1]
  8. Subramanian H, Froese A, Jönsson P, Schmidt H, Gorelik J, Nikolaev VO. Distinct submembrane localisation compartmentalises cardiac NPR1 and NPR2 signalling to cGMP. Nat Commun. 2018;9:2446. [pubmed] [Project 4] [Project 6]
  9. Ter-Avetisyan G, Dumoulin A, Herrel A, Schmidt H, Strump J, Afzal S, Rathjen FG. Loss of axon bifurcation in mesencephalic trigeminal neurons impairs the maximal biting force in Npr2-deficient mice. Front Cell Neurosci. 2018;12:153. [pubmed] [Project 6]
  10. Beck K, Friebe A, Voussen B. Nitrergic signaling via interstitial cells of Cajal and smooth muscle cells influences circular smooth muscle contractility in murine colon. Neurogastroenterol Motil. 2018; ;30:e13300. [pubmed] [Project 3]
  11. Dumoulin A, Ter-Avetisyan G, Schmidt H, Rathjen FG. Molecular analysis of sensory axon branching unraveled a cGMP-dependent signaling cascade. Int J Mol Sci. 2018;19: pii: E1266. Review [pubmed] [Project 6]
  12. Lehners M*, Dobrowinski D*, Feil S, Feil R. cGMP signaling and vascular smooth muscle cell plasticity. J Cardiovasc Dev Dis. 2018;5: pii: E20. Review [pubmed] [Project 1] *authors contributed equally
  13. Stroppel AS, Paolillo M, Ziegler T, Feil R, Stafforst T. Npom-protected NONOate enables light-triggered NO/cGMP signalling in primary vascular smooth muscle cells. Chembiochem. 2018;19:1312-1318. [pubmed] [Project Z]
  14. Bork NI, Nikolaev VO. cGMP signaling in the cardiovascular system-the role of compartmentation and its live cell imaging. Int J Mol Sci. 2018;19. pii: E801. Review [pubmed] [Project 4]
  15. Cheron G, Márquez-Ruiz J, Cheron J, Prigogine C, Ammann C, Lukowski R, Ruth P, Dan B. Purkinje cell BKchannel ablation induces abnormal rhythm in deep cerebellar nuclei and prevents LTD. Sci. Rep. 2018;8:4220. [pubmed] [Project 5]
  16. Matei AE, Beyer C, Györfi AH, Soare A, Chen CW, Dees C, Bergmann C, Ramming A, Friebe A, Hofmann F, Distler O, Schett G, Distler JHW. Protein kinases G are essential downstream mediators of the antifibrotic effects of sGC stimulators. Ann Rheum Dis. 2018;77:459. [pubmed] [Project 3]
  17. Špiranec K, Chen W, Werner F, Nikolaev VO, Naruke T, Koch F, Werner A, Eder-Negrin P, Diéguez-Hurtado R, Adams RH, Baba HA, Schmidt H, Schuh K, Skryabin BV, Movahedi K, Schweda F, Kuhn M. Endothelial C-type natriuretic peptide acts on pericytes to regulate microcirculatory flow and blood pressure. Circulation. 2018; pii: CIRCULATIONAHA.117.033383. [pubmed] [Project 4] [Project 6]
  18. Wright PT, Bhogal NK, Diakonov I, Pannell LMK, Perera RK, Bork NI, Schobesberger S, Lucarelli C, Faggian G, Alvarez-Laviada A, Zaccolo M, Kamp TJ, Balijepalli RC, Lyon AR, Harding SE, Nikolaev VO, Gorelik J. Cardiomyocyte membrane structure and cAMP compartmentation produce anatomical variation in β2AR-cAMP responsiveness in murine hearts. Cell Rep. 2018;23:459-69. [pubmed] [Project 4]
  19. Pavlaki N, Nikolaev VO. Imaging of PDE2- and PDE3-mediated cGMP-to-cAMP cross-talk in cardiomyocytes. J Cardiovasc Dev Dis. 2018;5. pii: E4. Review [pubmed] [Project 4]
  20. Friebe A, Voußen B, Groneberg D. NO-GC in cells 'off the beaten track'. Nitric Oxide. 2018;77:12-8. Review [pubmed] [Project 3]
  21. Frankenreiter S, Groneberg D, Kuret A, Krieg T, Ruth P, Friebe A, Lukowski R.  Cardioprotection by ischemic postconditioning and cGMP-elevating agents involves cardiomyocyte nitric oxide-sensitive guanylyl cyclase. Cardiovasc Res. 2018; doi: 10.1093/cvr/cvy039. [pubmed] [Project 3] [Project 5]
  22. Tröster P, Haseleu J, Petersen J, Drees O, Schmidtko A, Schwaller F, Lewin GR, Ter-Avetisyan G, Winter Y, Peters S, Feil S, Feil R, Rathjen FG, Schmidt H. The absence of sensory axon bifurcation affects nociception and termination fields of afferents in the spinal cord. Front Mol Neurosci. 2018;11:19. [pubmed] [Project 1] [Project 6] [Project 10] [Project Z]
  23. Dünnes S, Voussen B, Aue A, Groneberg K, Nikolaev V, Groneberg D, Friebe A. Phosphodiesterase 3A expression and activity in the murine vasculature is influenced by NO-sensitive guanylyl cyclase. Pflugers Arch. 2018;470:693-702. [pubmed] [Project 3] [Project 4]
  24. Burkard M, Kohl S, Krätzig T, Tanimoto N, Brennenstuhl C, Bausch AE, Junger K, Reuter P, Sothilingam V, Beck SC, Huber G, Ding XQ, Mayer AK, Baumann B, Weisschuh N, Zobor D, Hahn GA, Kellner U, Venturelli S, Becirovic E, Charbel Issa P, Koenekoop RK, Rudolph G, Heckenlively J, Sieving P, Weleber RG, Hamel C, Zong X, Biel M, Lukowski R, Seeliger MW, Michalakis S, Wissinger B, Ruth P. Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy. J Clin Invest. 2018;128(12):5663-5675. [pubmed] [Project 5]
  25. Singer W, Manthey M, Panford-Walsh R, Matt L, Geisler HS, Passeri E, Baj G, Tongiorgi E, Leal G, Duarte CB, Salazar IL, Eckert P, Rohbock K, Hu J, Strotmann J, Ruth P, Zimmermann U, Rüttiger L, Ott T, Schimmang T, Knipper M. BDNF-Live-Exon-Visualization (BLEV) allows differential detection of BDNF transcripts in vitro and in vivo. Front Mol Neurosci. 2018;11:325. [pubmed] [Project 5] [Project 8]

 2017 Publications

  1. Füger P, Hefendehl JK, Veeraraghavalu K, Wendeln AC, Schlosser C, Obermüller U, Wegenast-Braun BM, Neher JJ, Martus P, Kohsaka S, Thunemann M, Feil R, Sisodia SS, Skodras A, Jucker M. Microglia turnover with aging and in an Alzheimer's model via long-term in vivo single-cell imaging. Nat Neurosci. 2017;20:1371-6. [pubmed] [Project Z]
  2. Shuhaibar LC, Robinson JW, Vigone G, Shuhaibar NP, Egbert JR, Baena V, Uliasz TF, Kaback D, Yee SP, Feil R, Fisher MC, Dealy CN, Potter LR, Jaffe LA. Dephosphorylation of the NPR2 guanylyl cyclase contributes to inhibition of bone growth by fibroblast growth factor. Elife. 2017;6. pii: e31343. [pubmed] [Project Z]
  3. Podewin T, Broichhagen J, Frost C, Groneberg D, Ast J, Meyer-Berg H, Fine NHF, Friebe A, Zacharias M, Hodson DJ, Trauner D, Hoffmann-Röder A. Optical control of a receptor-linked guanylyl cyclase using a photoswitchable peptidic hormone. Chem Sci. 2017;8:4644-53. [pubmed] [Project 3]
  4. Robinson JW, Egbert JR, Davydova J, Schmidt H, Jaffe LA, Potter LR. Dephosphorylation is the mechanism of fibroblast growth factor inhibition of guanylyl cyclase-B. Cell Signal. 2017;40:222-9. [pubmed] [Project 6]
  5. Lu R, Flauaus C, Kennel L, Petersen J, Drees O, Kallenborn-Gerhardt W, Ruth P, Lukowski R, Schmidtko A. KCa3.1 channels modulate the processing of noxious chemical stimuli in mice. Neuropharmacology. 2017;125:386-95. [pubmed] [Project 5] [Project 10]
  6. Friebe A, Sandner P, Schmidtko A. Meeting report of the 8th International Conference on cGMP "cGMP: generators, effectors, and therapeutic implications" at Bamberg, Germany, from June 23 to 25, 2017. Naunyn Schmiedebergs Arch Pharmacol. 2017;390:1177-88. Review [pubmed] [Project 3] [Project 10]
  7. Frankenreiter S, Bednarczyk P, Kniess A, Bork N, Straubinger J, Koprowski P, Wrzosek A, Mohr E, Logan A, Murphy MP, Gawaz M, Krieg T, Szewczyk A, Nikolaev VO, Ruth P, Lukowski R. cGMP-elevating compounds and ischemic conditioning provide cardioprotection against ischemia and reperfusion injury via cardiomyocyte-specific BK channels. Circulation. 2017;136:2337-55. [pubmed] [Project 4] [Project 5]
  8. Donzelli S, Goetz M, Schmidt K, Wolters M, Stathopoulou K, Diering S, Prysyazhna O, Polat V, Scotcher J, Dees C, Subramanian H, Butt E, Kamynina A, Schobesberger S, King S.B, Nikolaev VO, de Wit C, Leichert LI, Feil R, Eaton P, Cuello F. Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity. Sci Rep. 2017;7:9938. [pubmed] [Project 1] [Project 4] [Project Z]
  9. Möhrle D, Reimann K, Wolter S, Wolters M, Varakina K, Mergia E, Eichert N, Geisler HS, Sandner P, Ruth P, Friebe A, Feil R, Zimmermann U, Koesling D, Knipper M, Rüttiger L. NO-sensitive guanylate cyclase isoforms NO-GC1 and NO-GC2 contribute to noise-induced inner hair cell synaptopathy. Mol Pharmacol. 2017;92:375-88. [pubmed] [Project 1] [Project 2] [Project 3] [Project 5] [Project 8] [Project Z]
  10. Thunemann M, Schörg BF, Feil S, Lin Y, Voelkl J, Golla M, Vachaviolos A, Kohlhofer U, Quintanilla-Martinez L, Olbrich M, Ehrlichmann W, Reischl G, Griessinger CM, Langer HF, Gawaz M, Lang F, Schäfers M, Kneilling M, Pichler BJ, Feil R. Cre/lox-assisted non-invasive in vivo tracking of specific cell populations by positron emission tomography. Nat Commun. 2017;8:444. [pubmed] [Project 1] [Project Z] [News Article] [News Article 2] [Eberle Innovation Award]
  11. Kraft AE, Nikolaev VO. FRET microscopy for real-time visualization of second messengers in living cells. Methods Mol Biol. 2017;1563:85-90. [pubmed] [Project 4]
  12. Kallenborn-Gerhardt W, Möser CV, Lorenz JE, Steger M, Heidler J, Scheving R, Petersen J, Kennel L, Flauaus C, Lu R, Edinger AL, Tegeder I, Geisslinger G, Heide H, Wittig I, Schmidtko A. Rab7 - a novel redox target that modulates inflammatory pain processing. Pain. 2017;158:1354-65. [pubmed] [Project 10]
  13. Berisha F, Nikolaev VO. Cyclic nucleotide imaging and cardiovascular disease. Pharmacol Ther. 2017;175:107-15. [pubmed] [Project 4]
  14. Straubinger J, Boldt K, Kuret A, Deng L, Krattenmacher D, Bork N, Desch M, Feil R, Feil S, Nemer M, Ueffing M, Ruth P, Just S, Lukowski R. Amplified pathogenic actions of angiotensin II in cysteine-rich LIM-only protein 4-negative mouse hearts. FASEB J. 2017;31:1620-38. [pubmed] [Project 1] [Project 5] [Project Z]

 2016 Publications

  1. Feil R. Viagra releases the brakes on melanoma growth. Mol Cell Oncol. 2016;4:e1188874. [pubmed] [Project 1] [Project Z]
  2. Groneberg D, Voussen B, Friebe A. Integrative control of gastrointestinal motility by nitric oxide. Curr Med Chem. 2016;23:2715-35. [pubmed] [Project 3]
  3. Schmidt H, Peters S, Frank K, Wen L, Feil R, Rathjen FG. Dorsal root ganglion axon bifurcation tolerates increased cyclic GMP levels: the role of phosphodiesterase 2A and scavenger receptor Npr3. Eur J Neurosci. 2016;44:2991-3000. [pubmed] [Project 1] [Project 6]
  4. Sanchez-Alonso JL, Bhargava A, O'Hara T, Glukhov AV, Schobesberger S, Bhogal NK, Sikkel MB, Mansfield C, Korchev YE, Lyon AR, Punjabi PP, Nikolaev VO, Trayanova NA, Gorelik J. Microdomain-specific modulation of L-type calcium channels leads to triggered ventricular arrhythmia in heart failure. Circ Res. 2016;119:944-55.  [pubmed] [Project 4]
  5. Swain L, Kesemeyer A, Meyer-Roxlau S, Vettel C, Zieseniss A, Güntsch A, Jatho A, Becker A, Nanadikar MS, Morgan B, Dennerlein S, Shah AM, El-Armouche A, Nikolaev VO, Katschinski DM. Redox imaging using cardiac myocyte specific transgenic biosensor mice. Circ Res. 2016;119:1004-16. [pubmed] [Project 4]
  6. Akiyama H, Fukuda T, Tojima T, Nikolaev VO, Kamiguchi H. Cyclic nucleotide control of microtubule dynamics for axon guidance. J Neurosci. 2016;36:5636-49. [pubmed] [Project 4]
  7. Möhrle D, Ni K, Varakina K, Bing D, Lee SC, Zimmermann U, Knipper M, Rüttiger L. Loss of auditory sensitivity from inner hair cell synaptopathy can be centrally compensated in the young but not old brain. Neurobiol Aging. 2016;44:173-84. [pubmed] [Project 8]
  8. Wobst J, von Ameln S, Wolf B, Wierer M, Dang TA, Sager HB, Tennstedt S, Hengstenberg C, Koesling D, Friebe A, Braun SL, Erdmann J, Schunkert H, Kessler T. Stimulators of the soluble guanylyl cyclase: promising functional insights from rare coding atherosclerosis-related GUCY1A3 variants. Basic Res Cardiol. 2016;111:51. [pubmed] [Project 2] [Project 3
  9. Chen W, Spitzl A, Mathes D, Nikolaev VO, Werner F, Weirather J, Špiranec K, Röck K, Fischer JW, Kämmerer U, Stegner D, Baba HA, Hofmann U, Frantz S, Kuhn M. Endothelial actions of ANP enhance myocardial inflammatory infiltration in the early phase after acute infarction. Circ Res. 2016;119:237-48. [pubmed] [Project 4]
  10. Ghosh A, Koziol-White CJ, Asosingh K, Cheng G, Ruple L, Groneberg D, Friebe A, Comhair SA, Stasch JP, Panettieri RA Jr, Aronica MA, Erzurum SC, Stuehr DJ. Soluble guanylate cyclase as an alternative target for bronchodilator therapy in asthma. Proc Natl Acad Sci U S A. 2016;113:E2355-62. [pubmed] [Project 3]
  11. Broekmans K, Stegbauer J, Potthoff SA, Russwurm M, Koesling D, Mergia E. Angiotensin II-induced hypertension is attenuated by reduction of sympathetic output in NO-sensitive guanylyl cyclase 1 knockout mice. J Pharmacol Exp Ther. 2016;356:191-9. [pubmed] [Project 2]  
  12. Segura-Puimedon M, Mergia E, Al-Hasani J, Aherrahrou R, Stoelting S, Kremer F, Freyer J, Koesling D, Erdmann J, Schunkert H, de Wit C, Aherrahrou Z. Proatherosclerotic effect of the α1-subunit of soluble guanylyl cyclase by promoting smooth muscle phenotypic switching. Am J Pathol. 2016;186:2220-31. [pubmed] [Project 2] 
  13. Dhayade S, Kaesler S, Sinnberg T, Dobrowinski H, Peters S, Naumann U, Liu H, Hunger RE, Thunemann M, Biedermann T, Schittek B, Simon HU, Feil S, Feil R. Sildenafil potentiates a cGMP-dependent pathway to promote melanoma growth. Cell Reports. 2016;14:2599-610. [pubmed] [Project 1] [Project Z] [News Article]

 2015 Publications

  1. Friebe A, Sandner P, Seifert R. From bedside to bench-meeting report of the 7th International Conference on cGMP "cGMP: generators, effectors and therapeutic implications" in Trier, Germany, from June 19th to 21st 2015. Naunyn Schmiedebergs Arch Pharmacol. 2015;388:1237-46. Review [pubmed] [Project 3] [News Article]
  2. Vogel S, Bodenstein R, Chen Q, Feil S, Feil R, Rheinlaender J, Schäffer T, Bohn E, Frick JS, Borst O, Münzer P, Walker B, Markel J. Csanyi G, Pagano PJ, Loughran P, Jessup ME, Watkins SC, Bullock GC, Sperry JL, Zuckerbraun BS, Billiar TR, Lotze MT, Gawaz M, Neal MD. Platelet-derived HMGB1 is a critical mediator for thrombosis. J Clin Invest. 2015;125:4638-54 [pubmed] [Project 1]
  3. Straubinger J, Schöttle, V, Bork N, Subramanian H, Dünnes S, Russwurm M, Gawaz M, Friebe A, Nemer M, Nikolaev VO, Lukowski R. Sildenafil does not prevent cardiomyocyte AT1R signaling induced heart hypertrophy and fibrosis. J Pharmacol Exp Ther. 2015;354:406-16 [pubmed] [Project 3] [Project 4][Project 5]
  4. Bettaga N, Jäger R, Dünnes S, Groneberg D, Friebe A. Cell-specific impact of nitric oxide-dependent guanylyl cyclase on arteriogenesis and angiogenesis in mice. Angiogenesis. 2015;18:245-54 [pubmed] [Project 3]
  5. Hübscher D, Nikolaev VO. Generation of transgenic mice expressing FRET biosensors. Methods Mol Biol. 2015;1294:117-29. Book Chapter [pubmed] [Project 4]
  6. Shuhaibar LC, Egbert JR, Norris RP, Lampe PD, Nikolaev VO, Thunemann M, Wen L, Feil R, Jaffe LA. Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles. Proc Natl Acad Sci U S A. 2015;112:5527-32 [pubmed] [Project 1] [Project 4] [Project Z]
  7. Brennenstuhl C, Tanimoto N, Burkard M, Wagner R, Bolz S, Trifunovic D, Kabagema-Bilan C, Paquet-Durand F, Beck SC, Huber G, Seeliger MW, Ruth P, Wissinger B, Lukowski R. Targeted ablation of Pde6h in mice reveals cross-species differences in cone and rod phototransduction protein inventory. J Biol Chem. 2015;290:10242-55 [pubmed] [Project 5] [Project 9]
  8. Perera RK, Sprenger J, Steinbrecher JH, Hübscher D, Lehnart SE, Abeßer M, Schuh K, El-Armouche A, Nikolaev VO. Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy. Circ Res. 2015;116:1304-11 [pubmed] [Project 4]
  9. Lu R, Bausch A, Kallenborn-Gerhardt W, Stoetzer C, Debruin N, Ruth P, Geisslinger G, Leffler A, Lukowski R, Schmidtko A. Slack channels expressed in sensory neurons control neuropathic pain in mice. J Neurosci. 2015;35:1125-35 [pubmed] [Project 5] [Project 10]

 2014 Publications

  1. Lorenz JE, Kallenborn-Gerhardt W, Lu R, Syhr KM, Eaton P, Geisslinger G, Schmidtko A. Oxidant-induced activation of cGMP-dependent protein kinase Iα mediates neuropathic pain after peripheral nerve injury. Antioxid Redox Signal. 2014;21:1504-15 [pubmed] [Project 10]
  2. Kallenborn-Gerhardt W, Lu R, Bothe A, Thomas D, Schlaudraff J, Lorenz JE, Lippold N, Real CI, Ferreirós N, Geisslinger G, Del Turco D, Schmidtko A. Phosphodiesterase 2A localized in the spinal cord contributes to inflammatory pain processing. Anesthesiology. 2014;121:372-82 [pubmed] [Project 10
  3. Lu R, Lukowski R, Sausbier M, Zhang DD, Sisignano M, Schuh CD, Kuner R, Ruth P, Geisslinger G, Schmidtko A. BKCa channels expressed in sensory neurons modulate inflammatory pain in mice. Pain. 2014;155:556-65 [pubmed] [Project 5] [Project 10]
  4. Thunemann M,Schmidt K, de Wit C, Han X, Jain RK, Fukumura D, Feil R. Correlative intravital imaging of cGMP signals and vasodilation in mice. Front Physiol. 2014;5:394. [pubmed] [Project 1]
  5. Chen JT, Guo D, Campanelli D, Frattini F, Mayer F, Zhou L, Kuner R, Heppenstall PA, Knipper M, Hu J. Presynaptic GABAergic inhibition regulated by BDNF contributes to neuropathic pain induction. Nat Commun. 2014;5:5331. [pubmed] [Project 8]
  6. Feil S, Fehrenbacher B, Lukowski R, Essmann, Schulze-Osthoff K, Schaller M, Feil R. Transdifferentiation of vascular smooth muscle cells to macrophage-like cells during atherogenesis. Circ Res. 2014;115:662-7 [pubmed] [Project 1] [Project 5] [News Article] [Press Release] [Editorial on this Article]
  7. Patrucco E, Domes K, Sbroggio M, Blaich A, Schlossmann J, Desch M, Rybalkin S, Beavo J, Lukowski R, Hofmann F. The roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis. Proc Natl Acad Sci U S A. 2014;111:12925-9 [pubmed[Project 5]
  8. Kröner C, Thunemann M, Vollmer S, Kinzer M, Feil R, Richert C. Endless: A purine-binding RNA motif that can be expressed in cells. Angew Chem Int Ed Engl. 2014;53:9189-202 [pubmed] [Project 1] [News Article 1] [News Article 2]
  9. Puttagunta R, Tedeschi A, Sória MG, Hervera A, Lindner R, Rathore KI, Gaub P, Joshi Y, Nguyen T, Schmandke A, Laskowski CJ, Boutillier AL, Bradke F, Di Giovanni S. PCAF-dependent epigenetic changes promote axonal regeneration in the central nervous system. Nat Commun. 2014;5:3527. [pubmed] [Project 7]
  10. Lies B, Gil V, Groneberg D, Seidler B, Saur D, Wischmeyer E, Jiménez M, Friebe A. Interstitial cells of Cajal mediate nitrergic inhibitory neurotransmission in the murine gastrointestinal tract. Am J Physiol Gastrointest Liver Physiol. 2014;307:G98-G106. [pubmed] [Project 3]
  11. Lukowski R, Krieg T, Rybalkin S, Beavo J, Hofmann F. Turning on cGMP-dependent pathways to treat cardiac dysfunctions: boom, bust and beyond. Trends Pharmacol Sci. 2014;35:404-13. Review [pubmed] [Project 5]
  12. Soltysinska E, Bentzen BH, Barthmes M, Hattel H, Thrush AB, Harper ME, Qvortrup K, Larsen FJ, Schiffer TA, Losa-Reyna J, Straubinger J, Kniess A, Thomsen MB, Brüggemann A, Fenske S, Biel M, Ruth P, Wahl-Schott C, Boushel RC, Olesen SP, Lukowski R. KCNMA1 encoded cardiac BK channels afford protection against ischemia-reperfusion injury. PLoS One. 2014;9:e103402. [pubmed] [Project 5]
  13. Corradini E, Vallur R, Raaijmakers LM, Feil S, Feil R, Heck AJ, Scholten A. Alterations in the cerebellar (phospho)proteome of a cGMP-dependent protein kinase knockout mouse. Mol Cell Proteomics. 2014;13:2004-16. [pubmed] [Project 1]
  14. Samantha A, Thunemann M, Feil R, Stafforst T. Upon the photostability of 8-nitro-cGMP and its caging as a 7-dimethylaminocoumarinyl ester. Chem Commun (Camb). 2014;50:7120-3. [pubmed] [Project 1]
  15. Vallur R, Kalbacher H, Feil R. Catalytic activity of cGMP-dependent protein kinase type I in intact cells is independent of N-terminal autophosphorylation. PLoS One. 2014;9:e98946. [pubmed] [Project 1]
  16. Sahaboqlu A, Tanimoto N, Bolz S, Garrido MG, Ueffing M, Seeliger MW, Löwenheim H, Ekström P, Paquet-Durand F. Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptors. Cell Death Dis. 2014;5:e1234. [pubmed] [Project 9]
  17. Götz KR, Sprenger JU, Perera RK, Steinbrecher JH, Lehnart SE, Kuhn M, Gorelik J, Balligand JL, Nikolaev VO. Transgenic mice for real-time visualization of cGMP in intact adult cardiomyocytes. Circ Res. 2014;114:1235-45. [pubmed] [Project 4]
  18. Wright PT, Nikolaev VO, O'Hara T, Diakonov I, Bhargava A, Tokar S, Schobesberger S, Shevchuk Al, Aikkel MB, Wilkinson R, Trayanova NA, Lyon AR, Harding SE, Gorelik J. Caveolin-3 regulates compartmentation of cardiomyocyte beta2-adrenergic receptor-mediated cAMP signaling. J Mol Cell Cardiol. 2014;67:38-48. [pubmed] [Project 4]
  19. Dettling J, Franz C, Zimmermann U, Lee SC, Bress A, Brandt N, Feil R, Pfister M, Engel J, Flamant F, Rüttinger LKnipper M. Autonomous functions of murine thyroid hormone receptor TRα and TRβ in cochlear hair cells. Mol Cell Endocrinol. 2014;382:26-37. [pubmed] [Project1] [Project 8]
  20. Ter-Avetisyan G, Rathjen FG, Schmidt H. Bifurcation of axons from cranial sensory neurons is disabled in the absence of Npr2-induced cGMP signaling. J Neurosci. 2014;34:737-47. [pubmed] [Project 6]
  21. Pirone A, Kurt S, Zuccotti A, Rüttiger L, Pilz P, Brown DH, Franz C, Schweizer M, Rust MB, Rübsamen R, Friauf E, Knipper M, Engel J. α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders. J Neurosci. 2014;34:434-45.[pubmed] [Project 8]

2013 Publications

  1. Stegbauer J, Friedrich S, Potthoff SA, Broekmans K, Cortese-Krott MM, Quack I, Rump LC, Koesling D, Mergia E. Phosphodiesterase 5 attenuates the vasodilatory response in renovascular hypertension. PLoS One. 2013;8:e80674. [pubmed] [Project 2]
  2. Typlt M, Mirkowski M, Azzopardi E, Rüttiger L, Ruth P, Schmid S. Mice with deficient BK channel function show impaired prepulse inhibition and spatial learning, but normal working and spatial reference memory. PLoS One. 2013;8:e81270. [pubmed] [Project 5] [Project 8]
  3. Lu R, Lukowski R, Susbie M, Zhang DD, Sisignano M, Schuh CD, Kuner R, Ruth P, Geisslinger G, Schmidtko A. BKCa channels expressed in sensory neurons modulate inflammatory pain in mice. Pain 2013;155:556-65. [pubmed] [Project 5] [Project 10]
  4. Turlo KA, Scapa J, Bagher P, Jones AW, Feil R, Korthuis RJ, Segal SS, Iruela-Arispe ML. β1-integrin is essential for vasoregulation and smooth muscle survival in vivo. Arterioscler Thromb Vasc Biol. 2013;33:2325-35. [pubmed] [Project 1]
  5. Kallenborn-Gerhardt W, Lu R, Syhr KM, Heidler J, von Melchner H, Geisslinger G, Bangsow T, Schmidtko A. Antioxidant activity of Sestrin 2 controls neuropathic pain after peripheral nerve injury. Antioxid Redox Signal. 2013;19:2013-23 [pubmed] [Project 10
  6. Fosberg K, Wuttke A, Quadat G, Cumakov PM, Wizenmann A, Di Giovanni S. The tumor suppressor p53 fine-tunes reactive oxygen species levels and neurogenesis via PI3 kinase signaling. J Neurosci. 2013;33:14318-30. [pubmed] [Project 7]
  7. Couto A, Oda S, Nikolaev VO, Soltesz Z, de Bono M. In vivo genetic dissection of O2 -evoked cGMP dynamics in a Caenorhabditis elegans gas sensor. Proc Natl Acad Sci U S A. 2013;110:E3301-10. [pubmed] [Project 4]
  8. Zhang L, Lukowski R, Gaertner F, Lorenz M, Legate KR, Domes K, Angermeier E, Hofmann F, Massberg S. Thrombocytosis as a response to high interleukin-6 levels in cGMP-dependent protein kinase I mutant mice. Arterioscler Thromb Vasc Biol. 2013;33:1820-8. [pubmed] [Project 5]
  9. Groneberg D, Lies B, König P, Jäger R, Seidler B, Klein S, Saur D, Friebe A. Cell-specific deletion of nitric oxide-sensitive guanylyl cyclase reveals a dual pathway for nitrergic neuromuscular transmission in the murine fundus. Gastroenterology. 2013;145:188-96.[pubmed] [Project 3]
  10. Methner C, Lukowski R, Grube K, Loga F, Smith RA, Murphy MP, Hofmann F, Krieg T. Protection through postconditioning or a mitochondria-targeted S-nitrosothiol is unaffected by cardiomyocyte-selective ablation of protein kinase G. Basic Res Cardiol. 2013;108:337. [pubmed] [Project 5]
  11. Rüttiger L, Singer W, Panford-Walsh R, Matsumoto M, Lee SC, Zuccotti A, Zimmermann U, Jaumann M, Rohbock K, Xiong H, Knipper M. The reduced cochlear output and the failure to adapt the central auditory response causes tinnitus in noise exposed rats. PLoS One. 2013;8:e57247. [pubmed] [Project 8]
  12. Erdmann J, Stark K, Esslinger UB, Rumpf PM, Koesling D, de Wit C, Kaiser FJ, Braunholz D, Medack A, Fischer M, Zimmermann ME, Tennstedt S, Graf E, Eck S, Aherrahrou Z, Nahrstaedt J, Willenborg C, Bruse P, Brænne I, Nöthen MM, Hofmann P, Braund PS, Mergia E, Reinhard W, Burgdorf C, Schreiber S, Balmforth AJ, Hall AS, Bertram L, Steinhagen-Thiessen E, Li SC, März W, Reilly M, Kathiresan S, McPherson R, Walter U, Cardiogram, Ott J, Samani NJ, Strom TM, Meitinger T, Hengstenberg C, Schunkert H. Dysfunctional nitric oxide signalling increases risk of myocardial infarction. Nature. 2013;504:432-6. [pubmed] [Project 2] [News Article]
  13. Thunemann M*, Wen L*, Hillenbrand M, Vachaviolos A, Feil S, Ott T, Han X, Fukumura D, Jain RK, Russwurm M, de Wit C, Feil R. Transgenic mice for cGMP imaging. Circ Res. 2013;113:365-71. [pubmed] [Project 1] [In this Issue] [News Article 1] [News Article 2]  *authors contributed equally
  14. Lies B, Groneberg D, Gambaryan S, Friebe A. Lack of effect of ODQ does not exclude cGMP signalling via NO-sensitive guanylyl cyclase. Br J Pharmacol. 2013;170:317-27. [pubmed] [Project 3]
  15. Duncker SV, Franz C, Kuhn S, Schulte U, Campanelli D, Brandt N, Hirt B, Fakler B, Blin N, Ruth P, Engel J, Marcotti W, Zimmermann U, Knipper M. Otoferlin couples to clathrin-mediated endocytosis in mature cochlear inner hair cells. J Neurosci. 2013;33:9508-19. [pubmed] [Project 5] [Project 8]
  16. Singer W, Geisler HS, Knipper M. The Geisler Method: Tracing activity-dependent cGMP plasticity changes upon double detection of mRNA and protein on brain slices. Methods Mol Biol. 2013;1020:223-33. Book Chapter [pubmed] [Project 8]
  17. Schmidt H, Ter-Avetisyan G, Rathjen FG. A genetic strategy for the analysis of individual axon morphologies in cGMP Signalling mutant mice. Methods Mol Biol. 2013;1020:193-204. Book Chapter [pubmed] [Project 6]
  18. Götz KR, Nikolaev VO. Advances and techniques to measure cGMP in intact cardiomyocytes. Methods Mol Biol. 2013;1020:121-9. Book Chapter [pubmed] [Project 4]
  19. Thunemann M, Fomin N, Krawutschke C, Russwurm M, Feil R. Visualization of cGMP with cGi biosensors. Methods Mol Biol. 2013;1020:89-120. Book Chapter [pubmed] [Project 1]
  20. Jäger R, Groneberg D, Lies B, Bettaga N, Kümmel M, Friebe A. Radioimmunoassay for the quantification of cGMP levels in cells and tissues. Methods Mol Biol. 2013;1020:63-72. Book Chapter [pubmed] [Project 3]
  21. Russwurm M, Russwurm C, Koesling D, Mergia E. NO/cGMP: The past, the present, and the future. Methods Mol Biol. 2013;1020:1-16. Book Chapter [pubmed][Project 2]
  22. Johnson SL, Kuhn S, Franz C, Ingham N, Furness DN, Knipper M, Steel KP, Adelman JP, Holley MC, Marcotti W. Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity. Proc Natl Acad Sci U S A. 2013;110:8720-5. [pubmed][Project 8]
  23. Klein S, Seidler B, Kettenberger A, Sibaev A, Rohn M, Feil R, Allescher HD, Vanderwinden JM, Hofmann F, Schemann M, Rad R, Storr MA, Schmid RM, Schneider G, Saur D. Interstitial cells of Cajal integrate excitatory and inhibitory neurotransmission with intestinal slow-wave activity. Nat Commun. 2013;4:1630. [pubmed] [Project 1]
  24. Sprenger JU, Nikolaev VO. Biophysical Techniques for Detection of cAMP and cGMP in Living Cells. Int J Mol Sci. 2013;14:8025-46. [pubmed] [Project 4]
  25. Rüttiger L, Singer W, Panford-Walsh R, Matsumoto M, Lee SC, Zuccotti A, Zimmermann U, Jaumann M, Rohbock K, Xiong H, Knipper M. The reduced cochlear output and the failure to adapt the central auditory response causes tinnitus in noise exposed rats. PLoS One. 2013;8:e57247. [pubmed] [Project 8]
  26. Chen L, Bi D, Tian L, McClafferty H, Steeb F, Ruth P, Knaus HG, Shipston MJ. Palmitoylation of the β4-subunit regulates surface expression of large conductance calcium-activated potassium channel splice variants. J Biol Chem. 2013;288:13136-44. [pubmed] [Project 5]
  27. Neitz A, Mergia E, Imbrosci B, Petrasch-Parwez E, Eysel UT, Koesling D, Mittmann T. Postsynaptic NO/cGMP increases NMDA receptor currents via hyperpolarization-activated cyclic nucleotide-gated channels in the hippocampus. Cereb Cortex. 2013;24:1923-36. [pubmed] [Project 2]
  28. Galmiche G, Labat C, Mericskay M, Aissa KA, Blanc J, Retailleau K, Bourhim M, Coletti D, Loufrani L, Gao-Li J, Feil R, Challande P, Henrion D, Decaux JF, Regnault V, Lacolley P, Li Z. Inactivation of serum response factor contributes to decrease vascular muscular tone and arterial stiffness in mice. Circ Res. 2013;112:1035-45. [pubmed] [Project 1]
  29. Sahaboglu A, Paquet-Durand O, Dietter J, Dengler K, Bernhard-Kurz S, Ekström PA, Hitzmann B, Ueffing M, Paquet-Durand F. Retinitis pigmentosa: rapid neurodegeneration is governed by slow cell death mechanisms. Cell Death Dis. 2013;4:e488. [pubmed] [Project 9]
  30. Singer W, Zuccotti A, Jaumann M, Lee SC, Panford-Walsh R, Xiong H, Zimmermann U, Franz C, Geisler HS, Köpschall I, Rohbock K, Varakina K, Verpoorten S, Reinbothe T, Schimmang T, Rüttiger L, Knipper M. Noise-induced inner hair cell ribbon loss disturbs central arc mobilization: a novel molecular paradigm for understanding tinnitus. Mol Neurobiol.  2013;47:261-79. [pubmed] [Project 8]
  31. Tanimoto N, Sothilingam V, Seeliger MW. Functional phenotyping of mouse models with ERG. Methods Mol Biol. 2013;935:69-78. Book Chapter [pubmed] [Project 9]