PD Dr. Lukas Rüttiger

Molecular Physiology of Hearing
Hearing Research Centre
Universität Tübingen
Elfriede Aulhorn Str. 5
72076 Tübingen


Tel.:     07071-29-88194
Fax:     07071-29-4950
E-Mail:  lukas.ruettiger(at)remove-this.uni-tuebingen.de
Website link

Date of birth    December 23, 1963

Curriculum Vitae

1984-1991Biology programme of study, Eberhard-Karls-Universität Tübingen
1991Diplom thesis at the Institute for Behavioural Physiology (Prof. Dr. rer. nat. K. Schmidt-Koenig). "Radio tracking and flight path analyses of homing pigeons: clock shift and influence of experience".
1991-1995PhD in Biology (Dr. rer. nat) at the Eberhard-Karls-Universität Tübingen (Prof. Dr. rer. nat. K. Schmidt-Koenig and Prof. Dr. med. E. Zrenner). "The importance of the temporal range of the visual system for colour discrimination and brightness sensation".
1995Postdoctoral position, granted by the German Research Council-ƒortune programme, at the Research Department for Experimental Ophthalmology at the University Eye Hospital in Tübingen with Prof. L.T. Sharpe
1997Postdoc position, granted by the DFG, at the Max-Planck-Institute for biophysical Chemistry in Göttingen, Department Neurobiology/Membrane Biophysics (Prof. Dr. E. Neher), workgroup Primate Retina and Colour Vision (Prof. Dr. Barry B. Lee).
2000Postdoc position, granted by the DFG, SFB and ƒ’ortune, at the Tübingen Hearing Research Centre, ORL Clinic Tübingen (Prof. Dr. med. H. P. Zenner) at the Department of Molecular Neurobiology in Tübingen with Prof. Dr. rer. nat. M. Knipper.
2009 - presentResearch position in the Tübingen Hearing Research Centre, ORL Clinic Tübingen (Prof. Dr. med. H. P. Zenner)
2013Habilitation in Neurosensorics at the Eberhard-Karls-University Tübingen: "Systembiologie gestörter Hörwahrnehmung (Lärmbedingte Hörstörungen und Tinnitus)"

Selected publications

1.    Schubert T, Gleiser C, Heiduschka P, Franz C, Nagel-Wolfrum K, Sahaboglu A, Weisschuh N, Eske G, Rohbock K, Rieger N, Paquet-Durand F, Wissinger B, Wolfrum U, Hirt B, Singer W, Rüttiger L, Zimmermann U, Knipper M. Deletion of Myosin VI causes slow retinal optic neuropathy and age-related macular degeneration (AMD)-like retinal phenotype. Cell Mol Life Sci. 2015;72:3953-69 [pubmed]

2.    Pirone A, Kurt S, Zuccotti A, Rüttiger L, Pilz P, Brown DA, Franz C, Schweizer M, Rust MB, Rübsamen R, Friauf E, Knipper M, Engel J. α2δ3 is essential for normal structure and function of auditory nerve synapses and is a novel candidate for auditory processing disorders. J Neurosci. 2014;34:434-45 [pubmed]

3.    Dettling J, Franz C, Zimmermann U, Lee SC, Bress A, Brandt N, Feil R, Pfister M, Engel J, Flamant F, Rüttiger L, Knipper M. Autonomous functions of murine thyroid hormone receptor TR alpha and TR beta in cochlear hair cells. Mol Cell Endocrinol. 2014;382:26-37 [pubmed]

4.    Typlt M, Mirkowski M, Azzopardi E, Rüttiger L, Ruth P, Schmid S. Mice with deficient BK channel function show impaired prepulse inhibition and spatial learning, but normal working and spatial reference memory. PLoS One. 2013;8:e81270 [pubmed]

5.    Zuccotti A, Lee SC, Campanelli D, Singer W, Satheesh SV, Patriarchi T, Geisler HS, Köpschall I, Rohbock K, Nothwang HG, Hu J, Hell JW, Schimmang T, Rüttiger L, Knipper M. L-type CaV1.2 deletion in the cochlea but not in the brainstem reduces noise vulnerability: implication for CaV1.2 mediated control of cochlear BDNF expression. Front Mol Neurosci. 2013;6:20 [pubmed]

6.    Rüttiger L, Singer W, Panford-Walsh R, Matsumoto M, Lee SC, Zuccotti A, Zimmermann U, Jaumann M, Rohbock K, Xiong H, Knipper M. The reduced cochlear output and the failure to adapt the central auditory response causes tinnitus in noise exposed rats. PLoS One. 2013;8:e57247 [pubmed]

7.    Föller M, Jaumann M, Dettling J, Saxena A, Pakladok T, Munoz C, Ruth P, Sopjani M, Seebohm G, Rüttiger L, Knipper M, Lang F. AMP-activated protein kinase in BK-channel regulation and protection against hearing loss following acoustic overstimulation. FASEB J. 2012;26:4243-53 [pubmed]

8.    Kurt S, Sausbier M, Rüttiger L Brandt N, Moeller CK, Kindler J, Sausbier U, Zimmermann U, van Straaten H, Neuhuber W, Engel J, Knipper M, Ruth P, Schulze H. Critical role for cochlear hair cell BK channels for coding the temporal structure and dynamic range of auditory information for central auditory processing. FASEB J. 2012;26:3834-43 [pubmed]

9.    Jaumann M, Dettling J, Gubelt M, Zimmermann U, Gerling A, François Paquet-Durand. Feil S, Wolpert S, Franz, C, Varakina K, Xiong H, Brandt N, Kuhn S, Geisler HS, Rohbock K, Ruth P, Schlossmann J, Hütter J, Sandner P, Feil R, Engel J, Knipper M, Rüttiger L. cGMP-Prkg1 signaling and Pde5 inhibition shelter cochlear hair cells and hearing function. Nat Med. 2012;18:252-9 [pubmed]

10.  Zampini V, Rüttiger L, Johnson SL, Franz C, Furness DN, Waldhaus J, Xiong H, Hackney CM, Holley MC, Offenhauser N, Di Fiore PP, Knipper M, Masetto S, Marcotti W. Eps8 regulates hair bundle length and functional maturation of mammalian auditory hair cells. PLoS Biol. 2011;9:e1001048 [pubmed]