PD Dr. Hannes Schmidt

Universität Tübingen
IFIB -€“ Interfakultäres Institut für Biochemie
Hoppe-Seyler-Str. 4
72076 Tübingen


Tel.: 07071-29-72458
Fax: 07071-29-3332
E-Mail: hannes.schmidt(at)remove-this.uni-tuebingen.de

Date of birth     October 4, 1968

Curriculum Vitae

1990-1995Diploma studies in Biology, MLU Halle and University Leipzig
1995Diploma thesis "Induction of immunological relevant proteins in individual Neurons"€™, MPI Martinsried, supervisor: Prof. Dr. H. Wekerle
1995Diploma degree in Biology at the University Leipzig (very good)
1995-1999Doctoral candidate at the MDC Berlin, supervisor: Prof. Dr. F. G. Rathjen, supported by a PhD fellowship of the Boehringer Ingelheim Fonds, Doctoral thesis "€™Intracellular mechanisms of axon guidance -€“ Gipc as a cytoplasmic binding partner of Neuropilin-1"€™
1999Doctor rer. nat. at the FU Berlin (magna cum laude)
1999 - 2000Postdoc with Prof. Dr. F. G. Rathjen at the MDC Berlin
2000 - 2002Research fellow in the lab of Dr. A. Pini, MRC Centre for Developmental Neurobiology at King'€™s College London, UK, supported by a Marie Curie fellowship by the EC
2002 - 2013Postdoc with Prof. Dr. F. G. Rathjen at the MDC Berlin ("€˜A cGMP signalling cascade regulates the bifurcation of sensory axons")
2005 - 2013Project leader within the SFB 665 "€™Developmental disturbances in the nervous system"€™
2011Habilitation and venia legendi in "€˜Zoologie"€™ at the FU Berlin
2013 - presentProject leader within the DFG-FOR 2060 'cGMP signalling in cell growth and survival'
since 2016Senior scientist at the Interfakultäres Institut für Biochemie (IFIB), University of Tübingen

Selected publications

1.    Ter-Avetisyan G, Rathjen FG, Schmidt H. Bifurcation of axons from cranial sensory neurons is disabled in the absence of Npr2-induced cGMP signaling. J Neurosci. 2014;34:737-47. [pubmed]

2.    Schmidt H, Ter-Avetisyan G, Rathjen FG. A genetic strategy for the analysis of individual axon morphologies in cGMP signalling mutant mice. 'Guanylate cyclase and cyclic GMP' Meth Mol Biol (Springer Protocols). 2013;1020:193-204. Editors Krieg T and Lukowski R [pubmed]

3.    Schmidt H, Rathjen FG. Signalling mechanisms regulating axonal branching in vivo. Bioessays. 2010;32:977-85 [pubmed]

4.    Patzke C, Max KE, Behlke J, Schreiber J, Schmidt H, Dorner AA, Kröger S, Henning M, Otto A, Heinemann U, Rathjen FG. The coxsackievirus-adenovirus receptor reveals complex homophilic and heterophilic interactions on neural cells. J Neurosci. 2010;30:2897-910 [pubmed]

5.    Schmidt H, Stonkute A, Jüttner R, Schäffer S, Koesling D, Friebe A, Rathjen FG. C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons. Proc Natl Acad Sci U S A. 2009;106:16847-52 [pubmed]

6.    Schmidt H, Stonkute A, Jüttner R, Schäffer S, Buttgereit J, Feil R, Hofmann F, Rathjen FG. The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord. J Cell Biol. 2007;179:331-40 [pubmed]

7.    Knöll B, Schmidt H, Andrews W, Guthrie S, Pini A, Sundaresan V, Drescher U. On the topographic targeting of basal vomeronasal axons through Slit-mediated chemorepulsion. Development.  2003;130:5073-82 [pubmed]

8.    Schmidt H, Werner M, Heppenstall PA, Henning M, More MI, Kuhbandner S, Lewin GR, Hofmann F, Feil R, Rathjen FG. cGMP-mediated signalling via cGKIalpha is required for the guidance and connectivity of sensory axons. J Cell Biol. 2002;159:489-98 [pubmed]

9.    Neumann H, Schmidt H, Wilharm E, Behrens L, Wekerle H. Interferon gamma gene expression in sensory neurons: evidence for autocrine gene regulation. J Exp Med. 1997;186:2023-31 [pubmed]

10.  Neumann H, Schmidt H, Cavalie A, Jenne D, Wekerle H. Major histocompatibility complex (MHC) class I gene expression in single neurons of the central nervous system: differential regulation by interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha. J Exp Med. 1997;185:305-16 [pubmed]