Prof. Dr. Viacheslav O. Nikolaev

University Medical Center Hamburg-Eppendorf (UKE)
Institute of Experimental Cardiovascular Research
Martinistr. 52
20246 Hamburg

Tel.:     +49 (0) 40 7410 51391
Fax:     +49 (0) 40 7410 40180
E-Mail: v.nikolaev(at)
Website link

Date of birth    March 18, 1980

Curriculum Vitae

2002Diploma in Pharmacy, Chemical Pharmaceutical Academy,
2002Research stay, Biocenter, University Halle-Wittenberg
2003-2005PhD student, Institute of Pharmacology, University of Würzburg
2005PhD, Graduate School of Life Sciences, University of Würzburg
2005-2010Post-Doc, Bioimaging Center, University of Würzburg
2008HFSP short-term fellowship, NIH/NICHD, Bethesda, MD, USA
2009-2010Research Associate and Honorary Research Associate, Department of Cardiac Medicine, National Heart and Lung Institute, Imperial College London
2010-2014Group leader, Emmy-Noether Group of the DFG, Dept. Cardiology and Pneumology, Heart Research Center Göttingen, University of Göttingen
2014 - presentProfessor of Experimental Cardiovascular Research, University Medical Center Hamburg-Eppendorf (UKE)

Selected publications

1.    Perera RK, Sprenger J, Steinbrecher JH, Hübscher D, Lehnart SE, Abeßer M, Schuh K, El-Armouche A, Nikolaev VO. Microdomain switch of cGMP-regulated phosphodiesterases leads to ANP-induced augmentation of β-adrenoceptor-stimulated contractility in early cardiac hypertrophy. Circ Res. 2015;116:1304-11 [pubmed]

2.    Sprenger JU, Perera RK, Steinbrecher JH, Lehnart SE, Maier LS, Hasenfuss G, Nikolaev VO. In vivo model with targeted cAMP biosensor reveals changes in receptor-microdomain communication in cardiac disease. Nat Commun. 2015;6:6965 [pubmed]

3.    Shuhaibar LC, Egbert JR, Norris RP, Lampe PD, Nikolaev VO, Thunemann M, Wen L, Feil R, Jaffe LA. Intercellular signaling via cyclic GMP diffusion through gap junctions restarts meiosis in mouse ovarian follicles. Proc Natl Acad Sci U S A. 2015;112:5527-32 [pubmed]

4.    Götz KR, Sprenger JU, Perera RK, Steinbrecher JH, Lehnart SE, Kuhn M, Gorelik J, Balligand JL, Nikolaev VO. Transgenic mice for real time visualization of cGMP in intact adult cardiomyocytes. Circ Res. 2014;114:1235-45 [pubmed]

5.    Nakagawa H, Oberwinkler H, Nikolaev VO, Gaßner B, Umbenhauer S, Wagner H, Saito Y, Baba HA, Frantz S, Kuhn M. Atrial natriuretic peptide locally counteracts the deleterious effects of cardiomyocyte mineralcorticoid receptor activation. Circ Heart Fail. 2014;7:814-21 [pubmed]

6.    Börner S, Schwede F, Schlipp A, Berisha F, Calebiro D, Lohse MJ, Nikolaev VO. FRET measurements of intracellular cAMP concentrations and cAMP analog permeability in intact cells. Nat Protoc. 2011;6:427-38 [pubmed]

7.    Nikolaev VO, Moshkov A, Lyon AR, Miragoli M, Novak P, Paur H, Lohse MJ, Korchev YE, Harding SE, Gorelik J. Beta2-adrenergic receptor redistribution in heart failure changes cAMP compartmentation. Science. 2010;327:1653-7 [pubmed]

8.    Nikolaev VO, Lohse MJ. Novel techniques for real-time monitoring of cGMP in living cells. Handb Exp Pharmacol. 2009:229-43 [pubmed]

9.    Nikolaev VO, Bunemann M, Schmitteckert E, Lohse MJ, Engelhardt S. Cyclic AMP imaging in adult cardiac myocytes reveals far-reaching beta1-adrenergic but locally confined beta2-adrenergic receptor-mediated signaling. Circ Res. 2006;99:1084-91 [pubmed]

10.  Nikolaev VO, Gambaryan S, Lohse MJ. Fluorescent sensors for rapid monitoring of intracellular cGMP. Nat Methods. 2006;3:23-5 [pubmed]